DKK-1
Produktdaten
Dickkopf-1
Sample preparation
Centrifuge freshly collected blood as soon as possible
Store centrifuged samples at -20°C for longer storage.
Samples are stable up to 3 freeze and thaw cycles.
Hemolyzed or lipemic samples may cause erroneous results.
Reference values
Median = 34 pmol/l (n = 51)
| Product name | DKK-1 |
| Cat-Nr. | BI-20413 |
| Range | 0 – 160 pmol/l |
| Sensitivity | 1.25 pmol/l (STD2 10 pmol/l) |
| Incubation time | 3.5 hours |
| Sample volume | 20 µl |
| Sample type | Serum |
| Species | Human |
| Tests | 96 |
| Method | ELISA |
Intended use
Intended use:
Dickkopf-1(DKK-1) is a 28.67 kDa secreted protein that acts as soluble inhibitor of the WNT signalling pathway. This pathway contains lipid-modified glycoproteins that activate cell surface receptor-mediated signal transduction to regulate cell activities like: cell fate, proliferation, migration, polarity and gene expression.
DKK-1 regulates developmental processes of all kinds. Thus, DKK-1 is also involved in the regulation of bone metabolism as it effects osteoblast differentiation and in regulation of tumourgenetic activity.
Intended applications:
- Atherosclerosis
- Rheumatoid arthritis
- Myeloma bone disease
- Diffuse idiopathic skeletal hyperostosis
- Ankylosing spondylitis
- Monoclonal gammopathy of undetermined significance
- Glucocorticoid induced osteoporosis
- Oncology
